Game Ready > Science

These materials provide insight into the pathophysiology behind the safety, effectiveness, and applicability of the benefits of the Game Ready® System:

1.	Knight KL. Cryotherapy in sport injury management. 1995. Human Kinetics, Champaign, IL.
2.	Wilkerson GB. Treatment of the inversion ankle sprain through synchronous application of focal compression and cold. Athletic Training, JNATA. 1991;26:220-236.
3.	Cameron MH. Physical agents in rehabilitation from research to practice. 2003. W.B. Saunders Company, Philadelphia, PA.
4.	Sabiston KB et al. The effects of intermittent compression and cold on reducing edema in postacute ankle sprains. Journal of Athletic Training. 1992;27(2):140.

In addition to the references above, Game Ready regularly cites these materials:

Hubbard TJ, Denegar CR. Does cryotherapy improve outcomes with soft tissue injury? J Athl Train. 2004;39(3):278-279.

Schaser K-D, Stover JF, Melcher I et al. Local cooling restores microcirculatory hemodynamics after closed soft-tissue trauma in rats. J Trauma. 2006;61(3):642-649.

Dahl J, Li J, Bring DK-I, Renström P, Ackerman PW. Intermittent pneumatic compression enhances neurovascular ingrowth and tissue proliferation during connective tissue healing. A study in the rat. J Orthop Res. 2007;25:1185-1192.

Johansson K, Lie E, Ekdahl C, Lindfeldt J. A randomized study comparing manual lymph drainage with sequential pneumatic compression for treatment of postoperative arm lymphodema. Lymphology. 1998;31(2):56-64.

McGeown JG, McHale NG, Thornbury KD. Effects of varying patterns of external compression on lymph flow in the hindlimb of the anaesthetized sheep. J Physiol. 1988;397:449-457.

McGeown JG, McHale NG, Thornbury KD. The role of external compression and movement in lymph propulsion in the sheep hind limb. J Physiol 1987;387:83-93.

Capps/Mayberry. Cryotherapy and intermittent pneumatic compression for soft tissue trauma. January 2009.

Womochel KS, Trowbridge CA, Keller D. The effects of continuous cooling and cyclical compression on intramuscular temperatures and cardiovascular strain. Journal of Athletic Training. 2009;44(3):s87.

Trowbridge CA, Womochel KS, and Davis DR. The effects of continuous cooling and cyclical compression on intramuscular and surface temperatures of the distal quadriceps. Journal of Athletic Training. 2008;43(3):S58.